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anti-Chromogranin A, mAb (23A1)

YIF-LF-MA0140 100 µl INQ
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Additional Information

Product Data
Synonyms CHGA
Properties
Clone 23A1
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human CGA protein purified from E. coli.
Application Western Blot (1:2,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Chromogranin A (CGA) was identified as a major soluble protein in adrenal medullary chromaffin granules. CHGA derived peptides are also known as Catestatin, Vasostatin-I,-II, Prochromacin, Pancreastatin and Parastatin. CGA and its processed products are involved in the biogenesis of densecore secretory granules and have a role in immunity against microbes, and function as potential markers for several types of tumors. They have also been implicated in neurodegenerative disorders and cardiovascular diseases such as a hypertension. CGA accumulates in the senile and preamyloid plaques of Alzheimer’s disease, in Lewy bodies of Parkinson’s disease, and in the swollen neurons of Pick’s disease. Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Product References

1) Steinbrenner, H. et al (2006) Free Radic. Biol. Med. 40: 1513-1523. (General)
2) Burk, R.F. et al (2005) Annu. Rev. Nutr. 25: 215-235. (General)
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