Call +41-61-926-60-40 Fax +41-61-926-60-49

anti-Erk1/2, mAb (9B3)

YIF-LF-MA0134 100 µl INQ
Actions
Select size:

* Required Fields

Amount:
Add to Cart
Call +41-61-926-60-40
Fax +41-61-926-60-49
Contact Us!
MSDS

Additional Information

Product Data
Synonyms ERT2; ERK1; ERK-1; MAPK3; MAPK 3; p44-ERK1; p44-MAPK; EC=2.7.11.24; MAP Kinase 3; MAP Kinase Isoform p44; Insulin-stimulated MAP2 Kinase; Mitogen-activated Protein Kinase 3; ERT1; ERK2; MAPK1; ERK-2; MAPK 2; MAPK 1; p42-MAPK; MAP Kinase 1; MAP Kinase 2; M
Properties
Clone 9B3
Isotype Mouse IgG2b κ
Immunogen/Antigen Synthetic peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1).
Application Western Blot (1:2,000~5,000)
Crossreactivity Human, Mouse, Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase(ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4).

Product References

1) Smalley, K. (2003) Int. J. Cancer, 104, 527-532. (General)
2) Johnson, G.L. and Lapadat, R. (2002) Science, 298, 1911-1912. (General)
3) Kolch, W. (2000) Biochem. J. 351, 289-305. (General)
No reviews for this product yet.