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anti-PLC γ, mAb (2B1)

YIF-LF-MA0050 100 µl INQ
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Additional Information

Product Data
Synonyms PLC1; PLCG1; PLC-II; PLC-148; EC=3.1.4.11; PLC-γ-1; Phospholipase C-II; Phospholipase C-γ-1; Phosphoinositide Phospholipase C-γ-1; 1-Phosphatidylinositol 4;5-Bisphosphate PhosphodiEsterase γ-1
Properties
Clone 2B1
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application Western Blot (1:2,000)
Immunoprecipitation (1 μl)
Crossreactivity Human, Mouse, Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

The mammalian Phospholipase C (PLC) family has two closely related proteins, PLC1 and PLC2. The PLC isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCγ. Activated PLC catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLC-γ is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Product References

1) Katan, M. (1998) Biochim. Biophys. Acta, 1436, 5-17. (General)
2) Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. (General)
3) Wang, Z. et al. (1998) Mol. Cell. Biol. 18, 590-597. (General)
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