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anti-Peroxiredoxin 3, mAb (12B)

YIF-LF-MA0044 100 µl INQ
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Additional Information

Product Data
Synonyms AOP1; AOP-1; PRDX3; HBC189; Prx-III; EC=1.11.1.15; Peroxiredoxin-3; Peroxiredoxin III; Protein MER5 Homolog; Antioxidant Protein 1; Thioredoxin-dependent Peroxide Reductase, Mitochondrial
Properties
Clone 12B
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application ELISA
Western Blot (1:1,000)
ICC (20 μl/400 μl)
IHC-P
Crossreactivity Human, Mouse
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 6 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1). Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-κ-B in the cytosol.

Product References

1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)
2) Rhee Sue Goo et al. (2001) IUBMB Life. 52:35-41. (General)
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