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Olaparib

SYN-3043-M001 1 mg INQ
SYN-3043-M005 5 mg INQ
SYN-3043-M010 10 mg INQ
SYN-3043-M050 50 mg INQ
SYN-3043-M100 100 mg INQ
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Additional Information

Product Data
Synonyms AZD-2281; KU-59436; 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one
Properties
Formula C24H23FN4O3
MW 434.2
CAS 763113-22-0
Purity ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Origin Manufactured by SynKinase.
Other Product Data Target: PARP | Kinase Group: N/A | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key FDLYAMZZIXQODN-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.

Product Description

The PARP inhibitor Olaparib (AZD2281) is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing and antineoplastic activities. Olaparib selectively binds to and inhibits PARP (IC50 of 1-5nM in cell-free assays), inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

Product References

  1. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1: K.A. Menear, et al.; J. Med. Chem. 51, 6581 (2008)
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