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anti-Methylglyoxal [MG], mAb (3C)

JAI-MMG-030N 30 µg INQ
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Additional Information

Properties
Clone 3C
Isotype Mouse IgG2a
Immunogen/Antigen MG-modified keyhole-lympet hemocyanine.
Application Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Western Blot (see reference Nr. 4)
Crossreactivity All, Human
Specificity Recognizes MG-modified proteins (especially Argpyrimidine).
Purity Detail Protein A purified.
Formulation Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by JaICA.
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.

Product Description

Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products (AGE). MG reacts with arginine residue in protein and forms numerous numbers of adducts, such as argpyrimidine.

Product References

  1. Protein modification by a Maillard reaction intermediate methylglyoxal. Immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo: K. Uchida, et al.; FEBS Lett. 410, 313 (1997)
  2. Methylglyoxal Modification of Protein -Chemical and Immunochemical Characterization of Methylglyoxal-Arginine Adduct: T. Oya, et al.; J. Biol. Chem. 274, 18492 (1999)
  3. Advanced glycation and lipidoxidation of the peritoneal membrane: respective roles of serum and peritoneal fluid reactive carbonyl compounds: T. Miyata, et al.; Kidney Int. 58, 425 (2000)
  4. Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses: P.S. Padayatti, et al.; Invest. Ophthalmol. Vis. Sci. 42, 1299 (2001)
  5. High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells: P.S. Padayatti, et al.; Curr. Eye Res. 23, 106 (2001)
  6. Curcumin Inhibits ROS Formation and Apoptosis in Methylglyoxal- Treated Human Hepatoma G2 Cells: W.-H. Chan, et al.; Ann. N.Y. Acad. Sci. 1042, 372 (2005)
Immunohistochemical staining of MG adducts in atherosclerotic aorta using anti-MG, mAb (3C).
Immunohistochemical staining of MG adducts in atherosclerotic aorta using anti-MG, mAb (3C).
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