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anti-4-Hydroxy-2-hexenal [4-HHE], mAb (HHE53)

JAI-MHH-030N 30 µg INQ
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Additional Information

Properties
Clone HHE53
Isotype Mouse IgG1κ
Source/Host Ascites
Immunogen/Antigen HHE-modified keyhole-lympet hemocyanine.
Application Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Crossreactivity All, Human
Specificity Recognizes HHE-modified proteins (especially HHE-His Michael adducts).
Purity Detail Protein A purified.
Formulation Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by JaICA.
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.

Product Description

4-hydroxy-2-alkenal is one of the major lipid peroxidation products, and shows many biological effects such as high toxicity to cells. Among them, 4-hydroxy-2-hexenal (HHE) is an aldehyde formed during peroxidation of n-3 fatty acids such as docosahexaenoic acid. HHE is highly reactive aldehyde and reacts with histidine residue of protein to form Michael-addition type adducts.

Product References

  1. Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids: S. Yamada, et al.; J. Lipid. Res. 45, 626 (2004)
  2. Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateralsclerosis: N. Shibata, et al.; Brain Res. 1019, 170 (2004)
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