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Albocycline

BVT-0429-M001 1 mg $95.00
BVT-0429-M005 5 mg $285.00
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Additional Information

Product Data
Synonyms Ingramycin; Antibiotic SR 2077; Antibiotic TA 2407
Properties
Formula C18H28O4
MW 308.4
CAS 25129-91-3
Source/Host Chemicals Isolated from Streptomyces sp. S1168.
Purity ≥98% (HPLC, NMR)
Appearance Yellowish oil.
Solubility Soluble in DMSO, methanol, dichloromethane or acetone.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key BYWWNDLILWPPJP-VHONNXCJSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
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Product Description

  • 14-Membered macrolide without sugar moieties.
  • Antibiotic. Selective mainly against staphylococci (incl. MRSA).
  • Inhibitor of prolyl endopeptidase.
  • Insecticidal activity.
  • Inhibitor of nicotinic acid (nicotinate; NA) biosynthesis.

Product References

  1. Studies on a new antibiotic, albocycline. I. Isolation, purification and properties: N. Nagahamam, et al.; J. Antibiot. 5, 261 (1967)
  2. Mode of action of albocycline, an inhibitor of nicotinate biosynthesis: F. Reusser; J. Bact. 100, 11 (1969)
  3. Albocycline: structure determination by x-ray crystallography: R.C. Thomas & C.G. Chidester; J. Antibiot. 35, 1658 (1982)
  4. Biosynthesis of albocycline: origin of the carbon skeleton: A. Taddei & A. Zeeck; J. Antibiot. 50, 526 (1997)
  5. Albocycline- and carbomycin-type macrolides, inhibitors of human prolyl endopeptidases: C. Christner, et al.; J. Antibiot. 51, 368 (1998)
  6. New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus: N. Koyama, et al.; J. Antibiot. 66, 303 (2013)
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