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Saquayamycin B1

BVT-0382-C500 500 µg $95.00
BVT-0382-M001 1 mg $150.00
BVT-0382-M005 5 mg $450.00
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Additional Information

Properties
Formula C31H32O12
MW 596.6
CAS 99260-68-1
Source/Host Chemicals Isolated from Streptomyces nodosus.
Purity ≥98% (HPLC)
Appearance Orange powder.
Solubility Soluble in DMSO, methanol or chloroform.
Identity Determined by 1H-NMR and UV.
Origin Manufactured by BioViotica.
InChi Key CTSPXNCFVRSKKD-IGVHUSDSSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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Product Description

  • Angucycline antibiotic.
  • Antibacterial.
  • Antitumor compound.
  • Active against Gram-positive bacteria and P388 leukaemia cells.
  • Farnesyl-protein transferase inhibitor.
  • Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).

Product References

  1. Saquayamycins, new aquayamycin-group antibiotics: T. Uchida, et al.; J. Antibiot. 38, 1171 (1985)
  2. Angucycline group antibiotics: J. Rohr & R. Thiericke; Nat. Prod. Rep. 9, 103 (1992) (Review)
  3. Isolation of novel saquayamycins as inhibitors of farnesyl-protein transferase: R. Sekizawa, et al.; J. Antibiot. 49, 487(1996)
  4. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts: A. A. Khisal, et al.; J. Antibiot. 53, 496 (2000)
  5. Moromycins A and B: M. S. Abdelfattah, et al.; J. Nat. Prod. 71, 1569 (2008)
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