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Actinomycin X2

BVT-0375-M001 1 mg INQ
BVT-0375-M005 5 mg INQ
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Additional Information

Product Data
Synonyms Actinomycin A5; Actinomycin B2; Actinomycin V; Actinomycin D, 3A-(4-oxo-L-proline); NSC175006
Properties
Formula C62H84N12O17
MW 1269.4
CAS 18865-48-0
RTECS AU2010000
Source/Host Isolated from Streptomyces sp.
Purity ≥98% (HPLC)
Appearance Orange crystals.
Solubility Soluble in DMSO, methanol, acetone or chloroform.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key SMBASHZPOHFQRU-ILYIJYFNSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution protect from light at -20°C.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

  • Aniso-Actinomycin (4-Oxopro instead of Pro in the β-chain).
  • Antitumor and antiviral antibiotic.
  • Antituberculosis agent.
  • Has higher cytotoxicity towards cultured human leukemia (HL-60) cells than actinomycin D.
  • Apoptosis inducer. Forms a complex with DNA and blocks its biological activity.

Product References

  1. Actinomycin V as a Potent Differentiation Inducer of F5-5 Friend Leukemia Cells: H. Morioka, et al.; Agric. Biol. Chem. 49, 2835 (1985)
  2. Structure elucidation of a potent anti-MRSA antibiotic AM3, produced by Streptomyces sp.: Y. Lim, et al.; Agric. Chem. Biotech. 38, 516 (1995)
  3. Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites: M. Shimizu, et al.; J. Gen. Plant Pathol. 70, 66 (2004)
  4. The actinomycins: Anticancer agents from natural products: A. B. Mauger & H. Lackner; page 281, CRC Press (2005)
  5. Characterization of Streptomyces MITKK-103, a newly isolated Actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006)
  6. A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity: C. Chen, et al.; Appl. Microbiol. Biotechnol. 95, 919 (2012)
  7. Characterization of Streptomyces padanus JAU4234, a producer of actinomycin X2, fungichromin, and a new polyene macrolide antibiotic: Z.-Q. Xiong, et al.; Appl. Environ. Microbiol. 78, 589 (2012)
  8. Purification and structure determination of three bioactive molecules from a newly isolated Streptomyces sp. AH 47: A. Hamza, et al.; Int. J. Curr. Res. 5, 1548 (2013)
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