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BioViotica
Actinomycin X2
110
CHF
CHF 110.00
In stock
BVT-0375-M0011 mgCHF 110.00
BVT-0375-M0055 mgCHF 325.00
| Product Details | |
|---|---|
| Synonyms | Actinomycin A5; Actinomycin B2; Actinomycin V; Actinomycin D, 3A-(4-oxo-L-proline); NSC175006 |
| Product Type | Chemical |
| Properties | |
| Formula |
C62H84N12O17 |
| MW | 1269.4 |
| CAS | 18865-48-0 |
| RTECS | AU2010000 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Orange crystals. |
| Solubility | Soluble in DMSO, methanol, acetone or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | SMBASHZPOHFQRU-ILYIJYFNSA-N |
| Smiles | [H][C@]12CCCN1C(=O)[C@H](NC(=O)[C@H](NC(=O)C1=C3N=C4C(OC3=C(C)C=C1)=C(C)C(=O)C(N)=C4C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@]3([H])N(CCC3=O)C(=O)[C@H](NC1=O)C(C)C)[C@@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution protect from light at -20°C. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Aniso-Actinomycin (4-Oxopro instead of Pro in the β-chain).
- Antitumor and antiviral antibiotic.
- Antituberculosis agent.
- Has higher cytotoxicity towards cultured human leukemia (HL-60) cells than actinomycin D.
- Apoptosis inducer. Forms a complex with DNA and blocks its biological activity.
Product References
- Actinomycin V as a Potent Differentiation Inducer of F5-5 Friend Leukemia Cells: H. Morioka, et al.; Agric. Biol. Chem. 49, 2835 (1985)
- Structure elucidation of a potent anti-MRSA antibiotic AM3, produced by Streptomyces sp.: Y. Lim, et al.; Agric. Chem. Biotech. 38, 516 (1995)
- Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites: M. Shimizu, et al.; J. Gen. Plant Pathol. 70, 66 (2004)
- The actinomycins: Anticancer agents from natural products: A. B. Mauger & H. Lackner; page 281, CRC Press (2005)
- Characterization of Streptomyces MITKK-103, a newly isolated Actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006)
- A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity: C. Chen, et al.; Appl. Microbiol. Biotechnol. 95, 919 (2012)
- Characterization of Streptomyces padanus JAU4234, a producer of actinomycin X2, fungichromin, and a new polyene macrolide antibiotic: Z.-Q. Xiong, et al.; Appl. Environ. Microbiol. 78, 589 (2012)
- Purification and structure determination of three bioactive molecules from a newly isolated Streptomyces sp. AH 47: A. Hamza, et al.; Int. J. Curr. Res. 5, 1548 (2013)
- Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144: J. Liu, et al.; Anticancer Drugs 27, 156 (2016)
- Identification, Bioactivity, and Productivity of Actinomycins from the Marine-Derived Streptomyces heliomycini: D. Wang, et al.; Front. Microbiol. 8, 1147 (2017)
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