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Concanamycin C (high purity)

BVT-0254-C025 25 µg $80.00
BVT-0254-C100 100 µg $170.00
BVT-0254-C500 500 µg $510.00
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Additional Information

Product Data
Synonyms 4'-O-De(aminocarbonyl)concanamycin A
Properties
Formula C45H74O13
MW 823.1
CAS 81552-34-3
RTECS GK6887000
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, methanol, chloroform or acetonitrile; insoluble in water.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key XKYYLWWOGLVPOR-PLWOKYFKSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibiotic.
  • Vacuolar-type H+-ATPase inhibitor.
  • Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
  • Anti-osteoporotic.
  • Antiviral.
  • Immunosuppressive.
  • Antifungal and anti-yeast.

Product References

  1. Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 35, 1618 (1982)
  2. Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984)
  3. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993)
  4. Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem. 275, 167 (2000)
  5. Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry 40, 2816 (2001)
  6. Inhibitors of V-ATPase: old and new players: M. Huss, et al.; J. Exp. Biol. 212, 341 (2009)
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