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Nargenicin A1

BVT-0204-M001 1 mg $190.00
BVT-0204-M005 5 mg $560.00
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Additional Information

Product Data
Synonyms CP-47,444; CS682
Properties
Formula C28H37NO8
MW 515.6
CAS 70695-02-2
Source/Host Chemicals Isolated from Actinomyces sp. Gö301.
Purity ≥98% (HPLC)
Appearance Off-white powder.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key YEUSSARNQQYBKH-SIMZXIQRSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia.
  • More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin.
  • Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA.
  • Displays low cytotoxicity compared to erythromycin and spiramycin.

Product References

  1. Structure of natural antibiotic CP-47,444: W.D. Celmer et al., J. Am. Chem. Soc. 102, 4203-4209 (1980).
  2. 9-O-Esters of nodusmicin: B.J. Magerlein and S.A. Mizsak, J. Antibiot. 35, 111-112 (1981).
  3. Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1: D.E. Cane and C. Yang, J. Am. Chem. Soc. 106, 784-787 (1984).
  4. Biosynthesis of nargenicin and nodusmicin: W.C. Snyder and K.L. Rinehart, jr., J. Am. Chem. Soc. 106, 787-789 (1984).
  5. Nargenicin biosynthesis: D.E. Cane et al., J. Am. Chem. Soc. 115, 527-535 (1993).
  6. The chemistry of the Nargenicin macrolides: J. Kallmerten, in Studies in natural products chemistry (Ed.: A.-U. Rahman, Elsevier)17, 283-310 (1995).
  7. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682: J.K. Sohng et al., Arch. Pharm. Res. 31, 1339-1345 (2008).
  8. Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by HPLC: S.S. Cho et al., Arch. Pharm. Res. 32, 335-340 (2009).
  9. Nargenicin attenuates lipopolysaccharide-induced responses in BV-2 cells: J.C. Yoo et al., Neuroreport 20, 1007 (2009).
  10. Nargenicin enhances 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetal/MAPK pathways: S.H. Kim et al., Biochemical Pharmacology 77, 1694-1701 (2009).
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