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Bafilomycin C1

BVT-0068-M001 1 mg $150.00
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Additional Information

Product Data
Synonyms L-681,110A1; 2-Demethyl-2-methoxy-24-methyl-hygrolidin
Properties
Formula C39H60O12
MW 720.9
CAS 88979-61-7
Source/Host Chemicals Isolated from Streptomyces sp. Gö 14F.
Purity ≥98% (HPLC)
Appearance Yellow powder.
Solubility Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
Other Product Data May undergo transformation to methyl ketal on long term storage in methanol. We recommend the use of fresh solutions.
InChi Key WUDBXVQNMOTFEE-WSNZTHDZSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibiotic.
  • Specific vacuolar-type H+-ATPase inhibitor.
  • Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
  • Antibacterial, antifungal, insecticidal and anthelmintic.
  • Potential anti-osteoporotic agent in treating bone lytic diseases.
  • Neuroprotection inducer.

Product References

  1. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984)
  2. Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993)
  3. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
  4. Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) (Review)
  5. Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007)
  6. Low-dose Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. Pivtoraiko, et. al.; J. Neurochem. 114, 1193 (2010)
  7. Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption-implications for osteoclast quality: A. Neutzsky-Wulff, et. al.; BMC Musculoskel. Disord. 11, 1471 (2010)
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