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Bafilomycin C1

BVT-0068-M001 1 mg $150.00
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Product Data
Synonyms L-681,110A1; 2-Demethyl-2-methoxy-24-methyl-hygrolidin
Formula C39H60O12
MW 720.9
CAS 88979-61-7
Source/Host Chemicals Isolated from Streptomyces sp. Gö 14F.
Purity ≥98% (HPLC)
Appearance Yellow powder.
Solubility Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
Other Product Data May undergo transformation to methyl ketal on long term storage in methanol. We recommend the use of fresh solutions.
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic.
  • Specific vacuolar-type H+-ATPase inhibitor.
  • Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
  • Antibacterial, antifungal, insecticidal and anthelmintic.
  • Potential anti-osteoporotic agent in treating bone lytic diseases.
  • Neuroprotection inducer.

Product References

  1. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984)
  2. Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993)
  3. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
  4. Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) (Review)
  5. Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007)
  6. Low-dose Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. Pivtoraiko, et. al.; J. Neurochem. 114, 1193 (2010)
  7. Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption-implications for osteoclast quality: A. Neutzsky-Wulff, et. al.; BMC Musculoskel. Disord. 11, 1471 (2010)
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