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Bafilomycin B1

BVT-0004-C100 100 µg $50.00
BVT-0004-M001 1 mg $95.00
BVT-0004-M005 5 mg $340.00
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Additional Information

Product Data
Synonyms Setamycin; BRN4640118
Properties
Formula C44H65NO13
MW 815.9
CAS 88899-56-3
RTECS LX8920000
Source/Host Chemicals Isolated from Streptomyces hygroscopicus.
Purity ≥97% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO or acetone. Insoluble in water. Unstable in methanol.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key KFUFLYSBMNNJTF-APLCIVFZSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Macrolide antibiotic.
  • Specific vacuolar-type H+-ATPase inhibitor.
  • Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases.
  • Antitrypanosomal and antileishmanial compound.
  • Phytotoxic.
  • Influences the cell wall biosynthesis of Asp. niger.

Product References

  1. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984)
  2. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993)
  3. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997)
  4. Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004)
  5. Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006)
  6. Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy: G. Carr, et al.; Journal of Nat. Prod. 73, 422 (2010)
  7. Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. N. Pivtoraiko; J. Neurochem. 114, 1193 (2010)
  8. Vacuolar H(+)-ATPase plays a keyrole in cell wall biosynthesis of Aspergillus niger: D. Schachtschabel, et al.;  Fungalgenet. Biol. 49, 284 (2012)
  9. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii: W. Zhang, et al.; ChemBioChem 14, 301 (2013)
  10. Isolation and characterization of phytotoxic compounds produced by Streptomyces sp. AMC 23 from red mangrove(rhizophora mangle): E. Crevelin, et al.; Appl. Biochem. Biotechnol. 171, 1602 (2013)
  11. High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and chagas disease: F. Annang, et al.; J. Biomol. Screen. 20, 82 (2015)
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