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MOTS-c (human)

AG-CP3-0026-M001 1 mg INQ
AG-CP3-0026-M005 5 mg INQ
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Product Data
Synonyms H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c; MOTS3
Formula C101H152N28O22S2 . C2HF3O2
MW 2174.6 . 114.0
Sequence H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
CAS 1627580-64-6
Source/Host Synthetic.
Purity ≥95% (HPLC)
Appearance Solid lyophilized powder.
Solubility Soluble in water.
Crossreactivity Human
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

  • Mitochondria-derived peptide (MDP).
  • Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK).
  • Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice.
  • Potential anti-obesity and anti-aging compound.

Product References

  1. A mitochondrially encoded hormone ameliorates obesity and insulin resistance: K. Zarse & M. Ristow; Cell. Metab. 21, 355 (2015)
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance: C. Lee, et al.; Cell. Metab. 21, 443 (2015)
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