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CTRP3 (human) Competitive ELISA Kit

AG-45A-0042EK-KI01 96 wells $640.00
AG-45A-0042TP-KI01 2 x 96 wells $980.00
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Additional Information

Product Data
Synonyms Complement C1q Tumor Necrosis Factor-related Protein 3; Secretory Protein CORS26; C1QTNF3
Properties
Application Set Quantitative ELISA
Specificity Detects human CTRP3. Does not cross-react with other human CTRPs or Adiponectin.
Crossreactivity Human
Quantity 1 x 96 wells
2 x 96 wells (Twin Plex)
Sensitivity 1ng/ml
Range 0.001 to 1μg/ml
Sample Type Cell Culture Supernatant, Plasma, Serum
Assay Type Competitive
Detection Type Colorimetric
Product Type Kit
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.
Documents
Manual Download Document Download
Manual TwinPlex Download Document Download
MSDS Download Document Download
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Product Description

CTRP3 (C1qTNF-related protein 3) plays an important role in regulating both embryonic cartilage development and postnatal longitudinal bone growth. CTRP3 stimulation leads to ERK1/2-dependent cell proliferation in human osteosarcoma cell lines. Circulating CTRP3 levels correlate inversely with circulating leptin levels in mice. Administration of sufficient recombinant CTRP3 suppressed hepatic glucose output via inhibition of gluconeogenesis and lowered blood glucose levels in both normal and ob/ob mice. Visceral adipocytes or monocytes secrete CTRP3 that antagonizes lipopolysaccharide (LPS) via a physical interaction with the TLR4/MD-2 receptor complex. These CTRP3 associated metabolically beneficial or anti-inflammatory features make CTRP3 to an interesting biomarker.

Product References

  1. C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome: K.M. Choi, et al.; Diabetes 61, 2932 (2012)
  2. Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome: H.J. Yoo, et al.; PLOS One 8, e55744 (2013)
  3. Effects of a Combined Aerobic and Resistance Exercise Program on C1q/TNF-Related Protein-3 (CTRP-3) and CTRP-5 Levels: H.Y. Choi, et al.; Diabetes Care 36, 3321 (2013)
  4. Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris: K.M. Choi, et al.; Cardiovasc. Diabetol. 13, 14 (2014)
  5. Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)
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