|Synonyms||Complement C1q Tumor Necrosis Factor-related Protein 3; Secretory Protein CORS26; C1QTNF3|
|Application Set||Quantitative ELISA|
|Specificity||Detects human CTRP3. Does not cross-react with other human CTRPs or Adiponectin.|
|Quantity||1 x 96 wells
2 x 96 wells (Twin Plex)
|Range||0.001 to 1μg/ml|
|Sample Type||Cell Culture Supernatant, Plasma, Serum|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
|Handling Advice||After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.|
CTRP3 (C1qTNF-related protein 3) plays an important role in regulating both embryonic cartilage development and postnatal longitudinal bone growth. CTRP3 stimulation leads to ERK1/2-dependent cell proliferation in human osteosarcoma cell lines. Circulating CTRP3 levels correlate inversely with circulating leptin levels in mice. Administration of sufficient recombinant CTRP3 suppressed hepatic glucose output via inhibition of gluconeogenesis and lowered blood glucose levels in both normal and ob/ob mice. Visceral adipocytes or monocytes secrete CTRP3 that antagonizes lipopolysaccharide (LPS) via a physical interaction with the TLR4/MD-2 receptor complex. These CTRP3 associated metabolically beneficial or anti-inflammatory features make CTRP3 to an interesting biomarker.
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