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DLL4 (human):Fc (human) (rec.) (highly active mutant)

AG-40B-0176-C010 10 µg INQ
AG-40B-0176-C100 100 µg INQ
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Additional Information

Product Data
Synonyms Delta-like Protein 4; Delta4
Source/Host HEK 293 cells
Sequence Extracellular domain of human DLL4 (aa 27-529 plus mutations) are fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity Human
Specificity Interacts with human Notch1 with >20 fold increase in affinity relative to WT DLL4 (as confirmed by ELISA).
MW ~80kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 10µg size: 0.1mg/ml after reconstitution.
100µg size: 1mg/ml after reconstitution.
Reconstitution Reconstitute with 100µl sterile endotoxin-free water.
Formulation Lyophilized. Contains PBS.
Other Product Data UniProt link Q9NR61: DLL4 (human) [Precursor]
Product Type Protein
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
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Product Description

The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
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