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Asprosin (human) (rec.) (His)

AG-40B-0174-C010 10 µg INQ
AG-40B-0174-3010 3 x 10 µg INQ
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Additional Information

Product Data
Synonyms Fibrillin-1 C-terminal Cleavage Product; FBN1 C Terminal Cleavage Product
Source/Host E. coli
Sequence Human asprosin (aa 2732-2871) is fused at the C-terminus to a His-tag.
Crossreactivity Human
MW ~18kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 100µg size: 1 mg/ml
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data Uni-Prot link P35555: Asprosin (human)
Product Type Protein
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
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Product Description

Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein kinase A in the liver. Reduction of asprosin levels protect against metabolic syndrome-associated hyperinsulinism. Endogenous asprosin runs on SDS-PAGE at ~30kDa, while bacterially expressed recombinant asprosin runs at 18kDa. The difference of migration is probably due to predicted three N-linked glycosylation sites and potentially other post-translational modifications that are lacking in bacteria. Bacterially expressed recombinant asprosin retains the biological activity displayed by its endogenously expressed counterpart.
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