AdipoGen Life Sciences

IL-1β (human) (rec.) (untagged)

CHF 215.00
In stock
AG-40B-0023-C01010 µgCHF 215.00
AG-40B-0023-30103 x 10 µgCHF 430.00
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Product Details
Synonyms Interleukin-1β; IL-1F2
Product Type Protein
Properties
Source/Host E. coli
Sequence Human IL-1β (aa 117-269) is untagged.
Crossreactivity Human
Specificity Binds to human IL-1R.
Biological Activity Activates the NF-κB with an ED50 of <5ng/ml.
MW ~17kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.1EU/μg purified protein (LAL test; Lonza).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data UniProt link P01584: Interleukin-1β (human)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

IL-1β is produced by activated macrophages. IL-1β stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1β belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1β in most situations requires the inflammasome complex to be cleaved and secreted.

Product References
  1. Detection of Neurofilament Light Chain with Label-Free Electrolyte-Gated Organic Field-Effect Transistors: K. Solodka, et al.; Adv. Mater. Interfaces 2102341, (2022)
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