Additional Information
| Product Data | |
|---|---|
| Synonyms | C1qTNF-related Protein 13; C1QTNF13; C1QL3; C1ql; K100; Complement C1q Tumor Necrosis Factor-related Protein 13 |
| Properties | |
| Source/Host | E. coli |
| Sequence | The globular domain of human CTRP13 (aa 120-255) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~16kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg purified protein (LAL test; Lonza). |
| Reconstitution | Reconstitute in distilled water. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Product Type | Protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 6 months when stored at -20°C. |
| Documents | |
| MSDS |
Download
|
Product Description
CTRP13 (C1qTNF-related protein 13) belongs to a highly conserved family of adiponectin paralogs. CTRP13 is an adipokine that promotes glucose uptake in adipocytes, myotubes and hepatocytes via activation of the AMPK signaling pathway. CTRP13 ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway. CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase. CTRP13 has insulin-sensitizing activity and is important in glucose homeostasis. CTRP13 is preferentially expressed by adipose tissue and the brain in mice and predominantly by adipose tissue in humans.
NH2-terminal sequence analysis.
No reviews for this product yet.