Additional Information
| Product Data | |
|---|---|
| Synonyms | Fibroblast Growth Factor 19 |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence | Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus the Fc portion of human IgG1. |
| Crossreactivity | Human |
| MW | ~50kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Reconstitution | Reconstitute in distilled water. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2. |
| Other Product Data | Swiss-Prot link O95750: Fibroblast Growth Factor-19 (human) |
| Product Type | Protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
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Product Description
FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
NH2-terminal sequence analysis.
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