Additional Information
| Product Data | |
|---|---|
| Synonyms | Klotho β-like Protein; BKL; KLB |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence | The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| MW | ~180kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | ~0.3mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS. |
| Other Product Data | UniProt link Q86Z14: βKlotho (human) |
| Product Type | Protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
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Product Description
βKlotho (KLB) induces ERK1/2 phosphorylation in response to FGF19 treatment and significantly increases the interactions between FGF19 and FGFR4. It is a cofactor for the interaction of FGF21 with FGF receptor 1c in adipocytes, which allows FGF21 to stimulate GLUT1 expression, upregulating adipocyte insulin-dependent glucose uptake. bKlotho contributes to the transcriptional repression of cholesterol 7-α-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis.
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