anti-TLR10 (human), mAb (ABM3C85)

TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1β specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.