AdipoGen Life Sciences

anti-TLR9 (mouse), mAb (ABM4D70) (FITC)

CHF 410.00
In stock
AG-20T-0309F-C100100 µgCHF 410.00
More Information
Product Details
Synonyms Toll-like Receptor 9; CD289
Product Type Monoclonal Antibody
Properties
Clone ABM4D70
Isotype Rat IgG2aκ
Immunogen/Antigen Recombinant mouse TLR9 protein (aa 602-860).
Label/Conjugates FITC
Application Flow Cytometry: (0.25-1μg/106 cells)

Optimal conditions must be determined individually for each application.
Crossreactivity Mouse
Specificity Recognizes mouse TLR9.
Purity Protein G purified.
Concentration 0.2mg/ml
Formulation Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
Accession Number Q99MB1
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Do not freeze.
Protect from light.
Use/Stability Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

TLR9 (Toll-like Receptor 9) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 is expressed by numerous cells of the immune system such as B lymphocytes, monocytes, natural killer (NK) cells and plasmacytoid dendritic cells. It is expressed intracellularly, within the endosomal compartments and functions to alert the immune system of viral and bacterial infections by binding to DNA rich in CpG motifs. This nucleotide-sensing TLR is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (also called oligodinucleotides, ODNs), and consequently signals via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response and eventually activation of a Th1-biased adaptive immune attack. Specific TLR9 agonists have been shown to have substantial antitumor activity, making the TLR9 signaling pathway an interesting target for therapeutic research.

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