AdipoGen Life Sciences

anti-TLR3 (human), mAb (ABM15D5)

CHF 390.00
In stock
AG-20T-0301-C100100 µgCHF 390.00
More Information
Product Details
Synonyms Toll-like Receptor 3; CD283
Product Type Monoclonal Antibody
Properties
Clone ABM15D5
Isotype Mouse IgG1κ
Immunogen/Antigen Recombinant human TLR3 protein (aa 25-370).
Application

Flow Cytometry: (2μg/106 cells)
Western Blot: (2-4μg/ml)
Optimal conditions must be determined individually for each application.

Crossreactivity Human
Specificity

Recognizes human TLR3.

Purity Protein G purified.
Concentration 0.5mg/ml
Formulation Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Isotype Negative Control

Mouse IgG1 Isotype Control

Accession Number O15455
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.

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