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AdipoGen Life Sciences
anti-TLR2, mAb (ABM3A87)
390
CHF
CHF 390.00
In stock
AG-20T-0300-C100100 µgCHF 390.00
Figure 1: Western blot analysis of TLR2 using anti-TLR2, mAb (ABM3A87) (AG-20T-0300) at 2µg/ml on mouse embryonic liver lysate.
Figure 2: Immunohistochemical analysis of TLR2 in paraffin-embeded sections of A) human renal cell carincoma and B) human prostate tissue using anti-TLR2, mAb (ABM3A87) (AG-20T-0300) at 5µg/ml.
Figure 3: Intracellular flow cytometry analysis of TLR2 in PBMCs (lymphocytes) using 0.5µg/106 cells of anti-TLR2, mAb (ABM3A87) (AG-20T-0300). Green represents the isotype control; red represents anti-TLR2, mAb (ABM3A87). A goat anti-mouse PE conjugated secondary antibody was used.
| Product Details | |
|---|---|
| Synonyms | Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | ABM3A87 |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human TLR2 protein (aa 180-420). |
| Application |
Flow Cytometry: (0.5μg/106 cells) |
| Crossreactivity |
Human Mouse |
| Specificity |
Recognizes human and mouse TLR2. |
| Purity | Protein G purified. |
| Concentration | 0.5mg/ml |
| Formulation | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.
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